There are 56 colleges and universities in the U.S. state of South Carolina. The University of South Carolina in Columbia is the largest university in the state, by enrollment. Trident Technical College in North Charleston is the largest two-year college. The oldest institution is the College of Charleston, founded in 1770 and chartered in 1785. (from Wikipedia, CC BY-SA)
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Structural data from the U.S. Department of Education College Scorecard, last refreshed 4/20/2026.